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This free tool helps you to close all running applications with one click. It does not use system resources because it only sends close signal to all open windows on the desktop and goes out. Just place a shortcut to it in the Start Menu, Quick Launch or somewhere.
You can always add hotkey to this shortcut. It is really very handy if you are running ~20 applications and want to quit them all. It works like as you press the close button of each application.